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US 6,294,384 B1Granted
Compositions and methods based upon an isoform of p53
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsGiorgio Dell'Acqua, Michael J. Mann, Victor J. Dzau
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Abstract
The present invention is directed to an isoform of the p53 tumor suppressor and to polynucleotides that encode this isoform. The isoform may be used as a marker to indicate that cardiac cells have experienced hypoxia, as would occur during a myocardial infarction. In addition, vectors encoding the isoform may be transfected into cells as a means of regulating proliferation.
Claims20
An isolated isoform of p53, consisting of the amino acid sequence of SEQ ID NO:1.
An isolated human isoform of p53, wherein said isoform consists of the amino acid sequence of SEQ ID NO:3.
Dependencies are inferred from the claim text.