TRAF inhibitors
AssigneesGenentech, Inc., Tularik Inc.
InventorsDavid V. Goeddel, Mike Rothe
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Abstract
The invention concerns novel inhibitors of tumor necrosis factor receptor associated factor-(TRAF) mediated signal transduction. The invention encompasses the novel inhibitor proteins (I-TRAFs), nucleic acid encoding them, methods for their recombinant production, and their use in screening assays and as pharmaceuticals.
Claims6
An assay for identifying a molecule capable of modulating the association of an I-TRAF and a TRAF comprising (a) incubating a mixture comprising said I-TRAF and TRAF with a candidate molecule and (b) detecting of the ability of the candidate molecule to modulate I-TRAF/TRAF association.
Dependencies are inferred from the claim text.