Monoclonal antibodies with specificity for membrane-associated antigens
AssigneeDade Behring Marburg GmbH
InventorsKlaus Bosslet, Roland Kurrle, Hans Harald Sedlacek, Ernst-Jurgen Kanzy, Takako Katoh, Hans Ulrich Schorlemmer, Gerhard Luben
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Abstract
Monoclonal antibodies with specificity for membrane-associated antigens and methods of using them in detection of tumor-associated antigens arc described.
Claims19
Monoclonal antibodies selected from the group consisting of 250/183-DSM ACC2412, 431/26-DSM ACC2414, 494/32-DSM ACC 2410, and 495/36-DSM ACC2415.
The monoclonal antibody having amino acids encoded by the cDNA sequences for the variable regions set forth in FIG. 4.
The monoclonal antibody 494/32-DSM ACC 2410.
The monoclonal antibody 250/183-DSM ACC 2412.
The monoclonal antibody having amino acids encoded by the cDNA sequences for the variable regions set forth in FIG. 2.
The monoclonal antibody 431/26-DSM ACC 2414.
The monoclonal antibody having amino acids encoded by the cDNA sequences for the variable regions set forth in FIG. 3.
The monoclonal antibody 495/36-DSM ACC 2415.
An isolated antibody or antigen-binding fragment thereof having a binding affinity for a tumor-associated antigen, wherein the antibody binds to the same epitope as monoclonal antibody 494/32-DSM ACC 2410, monoclonal antibody 431/26-DSM ACC2414, or monoclonal antibody 495/36-DSM ACC 2415.
A method of detecting in vitro a tumor-associated antigen derived from a carcinoma of the breast, ovaries, colon, pancreas or lung by binding the monoclonal antibody 494/32-DSM ACC 2410, or fragment thereof, or monoclonal antibody 495/36-DSM ACC 2415, or fragment thereof, to said antigen, and measuring the amount of said binding.
Dependencies are inferred from the claim text.