Method for inhibiting pathogenic microbes in an animal using a haloperoxidase-halide-peroxide system

A method of selectively inhibiting the growth of pathogenic microbes while not eliminating normal flora in an animal with an infection, comprising the steps of:

• a) administering to the animal having said infection an amount of a haloperoxidase which is antiseptically effective, in the presence of
• i) a peroxide and
• ii) bromide or chloride,
• wherein the haloperoxidase is selected from the group consisting of myeloperoxidase and eosinophil peroxidase, and said haloperoxidase is employed without derivatization to enhance target microbe specificity or affinity,
• b) selectively binding said haloperoxidase to the pathogenic microbes,
• c) oxidizing the halide and
• d) selectively killing the pathogenic microbes while not eliminating the normal flora of the animal.

A method of selectively inhibiting the growth of pathogenic microbes while not eliminating normal flora in an animal in need of such treatment, comprising the steps of:

• a) administering to the animal an amount of a haloperoxidase which is therapeutically effective, in the presence of
• i) a peroxide and
• ii) bromide or chloride,
• wherein said haloperoxidase is selected from the group consisting of myeloperoxidase, eosinophil peroxidase and said haloperoxidase is employed without derivatization to enhance target microbe specificity or affinity,
• b) selectively binding said haloperoxidase to the pathogenic microbes,
• c) oxidizing the halide,
• d) selectively killing the pathogenic microbes while not eliminating the normal flora of the animal, and
• e) maintaining the ratio of chloride to peroxide in the range of about 1 to about 40,000 when the halide is chloride or maintaining the ratio of bromide to peroxide in the range of about 0.1 to about 4,000 when the halide is bromide, at the site of the pathogenic microbes.

A method of selectively inhibiting the growth of pathogenic microbes while not eliminating normal flora in an animal with an infection, comprising the steps of:

• a) administering to the animal having said infection an amount of a haloperoxidase which is antiseptically effective, in the presence of
• i) a peroxide and
• ii) bromide or chloride,
• wherein the haloperoxidase is selected from the group consisting of myeloperoxidase, eosinophil peroxidase and said haloperoxidase is employed without derivatization to enhance target microbe specificity or affinity,
• b) selectively binding said haloperoxidase to the pathogenic microbes,
• c) oxidizing the halide,
• d) selectively killing the pathogenic microbes while not eliminating the normal flora of the animal, and
• e) maintaining the ratio of chloride to peroxide in the range of about 1 to at about 40,000 when the halide is chloride or maintaining the ratio of bromide to peroxide in the range of about 0.1 to about 4,000 when the halide is bromide, at the site of the pathogenic microbes.