Pharmaceutical compositions for immunotherapy containing antibodies which specifically recognize the MHCII antigen of a patient to be treated
AssigneeGSF-Forschungszentrum fur Umwelt und Gesundheit GmbH
InventorsHorst Lindhofer, Stefan Thierfelder
Life of this patent
Estimating the term…
Abstract
The invention concerns medicaments containing antibodies which have at least one specificity and detect the MHCII antigen of a patient to be treated. The invention further concerns antibodies with two or more specificities which detect the MHCII antigen of a patient, and diagnostic compositions containing these antibodies.
Claims13
A method for treating residual tumor cells in a mammalian subject comprising:
- transplanting bone marrow cells from a donor to said subject wherein the immunocompetent cells of said donor transplanted to said subject are characterized by an MHCII-type antigen which differs from the MHCII type antigen expressed by said tumor cells;
- and
- administering to said subject a pharmaceutically effective amount of a composition comprising an antibody which selectively binds to MHCII antigen expressed by said tumor cells,
- whereby as a result of said selective binding, tumor cells carrying an antibody-MHCII antigen complex are destroyed.
The method of claim 10, wherein said antibody is coupled to a moiety selected from the group consisting of an enzyme, a toxic substance, a radionuclide, biotin and a superantigen.
Dependencies are inferred from the claim text.