Permeation cell for invitro determination of skin permeation of pharmaceutical drugs

Permeation cell for the in vitro determination of the permeation of pharmaceutical active ingredients through the skin, comprising a donor chamber (34) and an acceptor chamber (4) that is separable therefrom, a window lying between the donor chamber and the acceptor chamber for receiving sealingly a skin membrane, and sealingly closable filling and emptying openings in both chambers, characterised in that

• the acceptor chamber (4) is in the form of a cylindrical vessel having a closure (8;
• 50) at its upper end and a side window opening (6) in the region near its base;
• this window recieving said membrane in an upright position, and the donor chamber (34) is in the form of a connection piece that joins onto the acceptor chamber radially, wherein the cylindrical vessel is inserted removably into a housing (10) that fits closely around it, which housing has, in the region of the window opening (6) of the acceptor chamber, a corresponding wider opening (30), and
• the connection piece forming the donor chamber (34) is screwed removably onto the housing (10) concentrically with the window opening (6).