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US 6,232,434 B1Granted
Polymers for delivering nitric oxide in vivo
AssigneeDuke University Medical Center
InventorsJonathan S. Stamler, Eric J. Toone, Richard S. Stack
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AssigneeDuke University Medical Center
InventorsJonathan S. Stamler, Eric J. Toone, Richard S. Stack
Estimating the term…
Disclosed are novel polymers derivatized with at least one —SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized —S-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by polymerizing a compound represented by the following structural formula: R is an organic radical. Each X′ is an independently chosen aliphatic group or substituted aliphatic group. Preferably, each X′ is the same and is a C2-C6 alkylene group, more preferably —CH2—, —CH2CH2—, —CH2CH2CH2— or —CH2CH2CH2CH2—. p and m are independently a positive integer such that p+m is greater than two. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.
A polymer comprising at least one —SNO group per 600 amu of the polymer and at least one free alcohol or free thiol group per 600 amu of the polymer, wherein:
A polymer comprising one or more —SNO groups, wherein at least one of the —SNO groups is stabilized by a free thiol group or a free alcohol group.
A polymer prepared by polymerizing a compound represented by the following structural formula:
A method of preparing a polymer comprising stabilized S-nitrosyl groups, said method comprising the step of polymerizing a compound represented by the following structural formula:
An article capable of releasing NO wherein the article is coated with a polymer comprising at least one —SNO group per 600 amu of the polymer and at least one free alcohol or free thiol group per 600 amu of the polymer, wherein:
A method of delivering nitric oxide to a treatment site in a subject or to bodily fluid comprising the steps of:
A method of preparing an article capable of releasing NO, said method comprising coating an article with a polymer comprising at least one —SNO per 600 amu of the polymer and at least one free alcohol or free thiol group per 600 amu of the polymer, wherein:
A polymer prepared by reacting a solution comprising a cyclic polythiolated polysaccharide with a nitrating reagent under conditions suitable for nitrating a free thiol group.
Dependencies are inferred from the claim text.