Methods of applying monomeric compositions effective as wound closure devices
AssigneeClosure Medical Corporation
InventorsJeffrey G. Clark, Jeffrey C. Leung
Life of this patent
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Abstract
A method of joining together in vivo living tissue surfaces includes (a) holding together at least two tissue surfaces to form abutted tissue surfaces, (b) applying across the abutted tissue surfaces an excessive amount of an adhesive composition comprising at least one monomer that forms a medically acceptable polymer with an applicator having a porous applicator tip; and (c) maintaining the tissue surfaces in contact in vivo until the composition polymerizes to form a thick film of polymerized composition on the abutted tissue surface.
Claims30
A method of joining together surfaces, comprising:
- (a) holding together at least two surfaces to form abutted surfaces,
- (b) applying across said abutted surfaces an adhesive composition that is uniformly distributed comprising at least one monomer that forms a polymer with an applicator having a porous applicator tip;
- and
- (c) maintaining said abutted surfaces in contact until said composition polymerizes to form a film of polymerized composition across said abutted surfaces.
A film formed across abutted tissue surfaces made by a method comprising:
- (a) holding together at least two living tissue surfaces to form abutted surfaces,
- (b) applying across said abutted surfaces an adhesive composition that is uniformly distributed, comprising at least one monomer that forms a biocompatible polymer, with an applicator having a porous applicator tip;
- and
- (c) maintaining said abutted surfaces in contact until said composition polymerizes to form a film of polymerized composition across said abutted surfaces.
A method of forming a biocompatible film across abutted tissue surfaces, comprising
- (a) holding together at least two tissue surfaces to form abutted tissue surfaces,
- (b) applying across said abutted tissue surfaces an adhesive biocompatible monomer composition with an applicator having a porous applicator tip, and
- (c) allowing said composition to polymerize and form a biocompatible film across said abutted tissue surfaces having an in vivo film strength of at least 70 mmHg of pressure required to induce wound failure.
A device for dispensing a polymerizable or cross-linkable monomer material from an applicator, comprising a porous applicator tip with an average pore size of about 1 μm to about 500 μm.
A device for dispensing a polymerizable or cross-linkable monomer material composition, comprising an applicator containing said composition and having a porous applicator tip with an average pore size of about 1 μm to about 500 μm.
Dependencies are inferred from the claim text.