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US 6,200,977 B1Granted
Pyrimidine derivatives
AssigneeTularik Inc.
InventorsTimothy D. Cushing, Heather L. Mellon, Juan C. Jaen, John A. Flygare, Shi-Chang Miao, Xiaoqi Chen, Jay P. Powers
Life of this patent
Estimating the term…
Abstract
Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.
Claims84
A compound having the formula:
- wherein
- X is —NR3R4;
- Y is —N(R6)—;
- R1 is a member selected from the group consisting of —NO2, —C(O)R9, —CO2R10, —C(O)NR7R8, —S(O)mNR7R8, and —CN;
- R2 is a member selected from the group consisting of hydrogen alkyl, —O-alkyl, —S-alkyl, halogen and cyano;
- R3 and R4 are taken together with the nitrogen atom to which each is attached to form a 5-membered ring containing from one to three heteroatoms in the ring;
- R5 is a member selected from the group consisting of alkyl, aryl and arylalkyl;
- R6 is a member selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl;
- or is combined with R5 and the nitrogen atom to which R5 and R6 are attached to form a 5-, 6-, 7- or 8-membered ring;
- R7 and R8 are members independently selected from the group consisting of hydrogen and alkyl;
- R9 and R10 are members independently selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl;
- m is an integer of from 1 to 2;
- and
- said compound having a molecular weight of from about 150 to about 750, with the proviso that —Y—R5 is other than an imidazole ring.
11 more elements
A compound in accordance with claim 18, wherein R5 is selected from the group consisting of:
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound having the formula:
- wherein
- X is —NR3R4;
- Y is —N(R6)—;
- R1 is a member selected from the group consisting of —NO2, —C(O)R9, —CO2R10, —C(O)NR7R8, and —CN;
- R2 is a member selected from the group consisting of hydrogen, alkyl, —O-alkyl, —S-alkyl, halogen and cyano;
- R3 and R4 are taken together with the nitrogen atom to which each is attached to form a 5-membered ring containing from one to three heteroatoms in the ring;
- R5 is a member selected from the group consisting of alkyl, aryl and arylalkyl;
- R6 is a member selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl;
- or is combined with R5 and the nitrogen atom to which R5 and R6 are attached to form a 5-, 6-, 7- or 8-membered ring;
- R7 and R8 are members independently selected from the group consisting of hydrogen and alkyl;
- R9 and R10 are members independently selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl;
- m is an integer of from 1 to 2;
- and
- said compound having a molecular weight of from about 150 to about 750, with the proviso that —Y—R5 is other than an imidazole ring.
11 more elements
A method for preventing or suppressing a viral infection in a mammal, comprising administering to said mammal a viral infection suppressing amount of a compound having the formula:
- wherein
- X is —NR3R4;
- Y is —N(R6)—;
- R1 is a member selected from the group consisting of —NO2, —C(O)R9, —CO2R10, —C(O)NR7R8, —S(O)mNR7R8, and —CN;
- R2 is a member selected from the group consisting of hydrogen, alkyl, —O-alkyl, —S-alkyl, halogen and cyano;
- R3 and R4 are taken together with the nitrogen atom to which each is attached to form a 5-membered ring containing from one to three heteroatoms in the ring;
- R5 is a member selected from the group consisting of alkyl, aryl and arylalkyl;
- R6 is a member selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl;
- or is combined with R5 and the nitrogen atom to which R5 and R6 are attached to form a 5-, 6-, 7- or 8-membered ring;
- R7 and R8 are members independently selected from the group consisting of hydrogen and alkyl;
- R9 and R10 are members independently selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl;
- m is an integer of from 1 to 2;
- and
- said compound having a molecular weight of from about 150 to about 750, with the proviso that —Y—R5 is other than an imidazole ring.
11 more elements
Dependencies are inferred from the claim text.