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US 6,168,784 AGranted
N-terminal modifications of RANTES and methods of use
AssigneeGryphon Sciences
InventorsRobin E. Offord, Darren Thompson, Jill Wilken
Life of this patent
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Abstract
N-terminally modified RANTES derivatives are disclosed. The derivatives effectively block the inflammatory effects of RANTES, and are useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, and rheumatoid arthritis. Additionally, the compounds are useful for the treatment of HIV infection.
Claims9
A compound of the formula:
- R1-RANTES (2-68) (SEQ ID NO:2)
- where R1 is CH3—(CH2)n—X—;
- in which
- X is —C(O)—NH—CH2—C(O)—, —NHCH2—C(O)—, —ONH—CH2—C(O)—, —OCH2—CH2—C(O)—, —CH═CH—C(O)—, —C(O)—, or a covalent bond;
- and
- n is an integer of 4-8;
- or a pharmaceutically acceptable salt thereof.
4 more elements
A composition which comprises of a compound of the formula:
- R1-RANTES (2-68)
- where R1 is CH3—(CH2)n—X—;
- in which
- X is —C(O)—NH—CH2—C(O)—, —NHCH2—C(O)—, —ONH—CH2—C(O)—, —OCH2—CH2—C(O)—, —CH═CH—C(O)—, —C(O)—, or a covalent bond;
- and
- n is an integer of 4-8;
- or a pharmaceutically acceptable salt thereof;
- in admixture with one or more pharmaceutically acceptable excipients.
5 more elements
Dependencies are inferred from the claim text.