Method for modulating hemopoiesis
AssigneeImmunotech Developments Inc.
InventorsVladislav I. Deigin, Andrei M. Korotkov
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Abstract
A peptide of the formula I X--Glu--Trp--Y (I) wherein X is H or Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, .gamma.-aminobutyric acid, .xi.-aminocaproic acid, and Y is Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, .gamma.-aminobutyric acid, .xi.-aminocaproic acid, --OH, mono- or di-substituted amide (c.sub.1 -c.sub.3) and the uses therefore in modulating the immune system and hemopiesis.
Claims9
A method of modulating hemopoiesis in an animal comprising administering to the animal an effective amount of one or more of the peptides of formula I:
- X--Glu--Trp--Y (I)
- wherein X is H, Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, His, Lys, Arg .gamma.-aminobutyric acid, or .xi.-aminocaproic acid;
- Y is Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, Arg, .gamma.-aminobutyric acid, .xi.-aminocaproic acid, --OH, NH.sub.2, N.sub.2 H.sub.3, or a mono- or di-substituted amide (C.sub.1 -C.sub.3);
- with the proviso that when X is H, Y is not --OH and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.