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US 6,159,701 AGranted
Method and compositions for treating and diagnosing tumors using adenosine receptor activated cells
AssigneeLink Technology Incorporated
InventorConstance Neely
Life of this patent
Estimating the term…
Abstract
Methods of treating and/or imaging tumors utilize A.sub.1 adenosine-receptor activated cells (such as monocytes and macrophages) are described. Activated cells may be administered systemically or locally, and may be radiolabelled to provide imaging and diagnostic functions. Macrophages resident in tissues may be primed and activated for use in treating and imaging tumors.
Claims12
A method of imaging tumor cells in vivo in a subject, comprising:
- (a) obtaining a sample of treatment cells from a subject, said treatment cells selected from the group consisting of macrophages, monocytes and splenocytes;
- (b) priming said treatment cells by contact with a priming agent in an amount sufficient to prime said treatment cells;
- (c) labeling said treatment cells with a radiolabelled A1 adenosinc receptor agonist, said A1 adenosine receptor agonist provided in an amount sufficient and for a time sufficient to induce cytotoxicity in said treatment cells;
- and then
- (d) administering said labelled treatment cells to the subject in an amount effective to provide a radioimage of tumor cells present in said subject.
2 more elements
Dependencies are inferred from the claim text.