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AssigneeSurModics, Inc.
InventorsDavid L. Clapper, Melvin J. Swanson, Sheau-Ping Hu, Richard A. Amos, Terrence P. Everson
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A polybifunctional reagent is provided having a polymeric backbone, one or more pendent photoreactive moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.
A polybifunctional reagent comprising a plurality of molecules each comprising a polymeric backbone bearing (a) a plurality of pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (b) two or more pendent bioactive groups capable of specific, noncovalent interactions with complementary groups, the reagent being capable, upon activation of the photoreactive moieties, of forming a crosslinked material or surface coating in order to promote the attraction of such complementary groups, wherein the polymeric backbone comprises a synthetic polymer or copolymer selected from the group consisting of acrylics, vinyls, nylons, polyurethanes, polyethers, and biodegradable polymers selected from the group consisting of polylactic acid, polyglycolic acid, polydioxanones, polyanhydrides, and polyorthoesters, and wherein the reagent is the product of a synthetic process that includes the polymerization of monomers having said pendent photoreactive moieties with monomers selected from the group consisting of monomers having said pendent bioactive groups and monomers having pendent thermoreactive groups adapted to attach said bioactive groups, such that said photoreactive moieties and said bioactive groups are provided along the length of the polymeric backbone.
A polybifunctional reagent comprising a synthetic polymeric backbone bearing (a) a plurality of pendent photoreactive moieties in the form of photoactivatable ketones capable of being activated by exposure to a suitable energy source, and (b) two or more pendent bioactive groups capable of specific, noncovalent interactions with complementary groups and selected from the group consisting of proteins, peptides, amino acids, carbohydrates, and nucleic acids, wherein the polymeric backbone comprises a synthetic polymer or copolymer selected from the group consisting of acrylics, vinyls, nylons, polyurethanes, polyethers, and biodegradable polymers selected from the group consisting of polylactic acid, polyglycolic acid, polydioxanones, polyanhydrides, and polyorthoesters, and wherein the reagent is the product of a synthetic process that includes the polymerization of monomers having said pendent photoreactive moieties with monomers selected from the group consisting of monomers having said pendent bioactive groups and monomers having pendent thermoreactive groups adapted to attach said bioactive groups, such that said photoreactive moieties and said bioactive groups are provided along the length of the polymeric backbone.
A method of coating a biomaterial surface, the method comprising the steps of (a) providing a polybifunctional reagent comprising a polymeric backbone bearing (i) a plurality of pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (ii) two or more pendent bioactive groups capable of specific, noncovalent interactions with complementary groups, (b) contacting the surface with the reagent, and (c) activating the photoreactive moieties in order to crosslink the reagent molecules to themselves and/or to the surface, wherein the polymeric backbone comprises a synthetic polymer or copolymer selected from the group consisting of acrylics, vinyls, nylons, polyurethanes, polyethers, and biodegradable polymers selected from the group consisting of polylactic acid, polyglycolic acid, polydioxanones, polyanhydrides, and polyorthoesters and wherein the reagent is the product of a synthetic process that includes the polymerization of monomers having said pendent photoreactive moieties with monomers selected from the group consisting of monomers having said pendent bioactive groups and monomers having pendent thermoreactive groups adapted to attach said bioactive groups, such that said photoreactive moieties and bioactive groups are provided along the length of the polymeric backbone.
A method for forming a crosslinked biomaterial, the method comprising the steps of (a) providing a polybifunctional reagent comprising a polymeric backbone bearing (i) a plurality of pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (ii) two or more pendent bioactive groups capable of specific, noncovalent interactions with complementary groups, and (b) activating the photoreactive moieties to form intermolecular covalent bonds between adjacent reagent molecules in order to form a crosslinked biomaterial, wherein the polymeric backbone comprises a synthetic polymer or copolymer selected from the group consisting of acrylics, vinyls, nylons, polyurethanes, polyethers, and biodegradable polymers selected from the group consisting of polylactic acid, polyglycolic acid, polydioxanones, polyanhydrides, and polyorthoesters, and wherein the reagent is the product of a synthetic process that includes the polymerization of monomers having said pendent photoreactive moieties with monomers selected from the group consisting of monomers having said pendent bioactive groups and monomers having pendent thermoreactive groups adapted to attach said bioactive groups such that said photoreactive moieties and bioactive groups are provided along the length of the polymeric backbone.
A coated biomaterial surface, comprising the surface coated with the bound residues of an activated polybifunctional reagent that initially comprised a polymeric backbone bearing (a) a plurality of pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (b) two or more pendent bioactive groups capable of specific, noncovalent interactions with complementary groups, wherein the polymeric backbone comprises a synthetic polymer or copolymer selected from the group consisting of acrylics, vinyls, nylons, polyurethanes, polyethers, and biodegradable polymers selected from the group consisting of polylactic acid, polyglycolic acid, polydioxanones, polyanhydrides, and polyorthoesters, and wherein the reagent is the product of a synthetic process that includes the polymerization of monomers having said pendent photoreactive moieties with monomers selected from the group consisting of monomers having said pendent bioactive groups and monomers having pendent thermoreactive groups adapted to attach said bioactive groups, such that said photoreactive moieties and said bioactive groups are provided along the length of the polymeric backbone.
A crosslinked material comprising the bound residues of an activated polybifunctional reagent that initially comprised a polymeric backbone bearing (a) a plurality of pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (b) two or more pendent bioactive groups capable of specific, noncovalent interactions with complementary groups, wherein the polymeric backbone comprises a synthetic polymer or copolymer selected from the group consisting of acrylics, vinyls, nylons, polyurethanes, polyethers, and biodegradable polymers selected from the group consisting of polylactic acid, polyglycolic acid, polydioxanones, polyanhydrides, and polyorthoesters, and wherein the reagent is the product of a synthetic process that includes the polymerization of monomers having said pendent photoreactive moieties with monomers selected from the group consisting of monomers having said pendent bioactive groups and monomers having pendent thermoreactive groups adapted to attach said bioactive groups, such that said photoreactive moieties and said bioactive groups are provided along the length of the polymeric backbone.
Dependencies are inferred from the claim text.