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US 6,080,409 AGranted
Immunostimulatory method
AssigneeDendreon Corporation
InventorsReiner Laus, Curtis Landon Ruegg, Hongyu Wu
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Abstract
Disclosed are therapeutic compositions and methods for inducing cytotoxic T cell responses in vitro and in vivo. The therapeutic compositions consist of antigen presenting cells activated by contact with a polypeptide complex constructed by joining together a dendritic cell-binding protein and a polypeptide antigen. Also disclosed are expression vectors and systems for producing the polypeptide complexes.
Claims7
A method of inducing a T cell-mediated cellular immune response to a soluble peptide antigen in a mammalian subject, comprising
- isolating antigen presenting cells (APCs) from the subject;
- exposing said APCs in vitro to a conjugate of granulocyte macrophage stimulating factor (GM-CSF) covalently linked to the soluble peptide antigen under conditions effective to activate the responder proliferation activity of the APCs;
- as evidenced by the ability of said APCs to stimulate proliferation of responder cells in vitro;
- administering said activated APCs to the subject.
1 more element
Dependencies are inferred from the claim text.