Compositions comprising hemostatic compounds and bioabsorbable polymers
AssigneeGenzyme Corporation
InventorsKeith E. Greenawalt, Julia B. Gershkovich
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Abstract
Solid, fibrous bioabsorbable hemostatic compositions containing a bioabsorbable polymer and a hemostatic compound, methods for making the hemostatic compositions, and methods for using the hemostatic compositions are disclosed.
Claims42
A solid, bioabsorbable hemostatic composition comprising a bioabsorbable polymer and a hemostatic compound, wherein the hemostatic compound is dispersed throughout the hemostatic composition, said hemostatic compound prepared by combining, in a non-aqueous solvent, thrombin, fibrinogen and a calcium salt, wherein said fibrinogen is not activated by thrombin during processing.
A method of making a solid, bioabsorbable hemostatic composition comprising the steps of
- a) admixing a bioabsorbable polymer and a hemostatic compound in a non-aqueous solvent to form a fibrous pulp, said hemostatic compound comprising thrombin, fibrinogen and a calcium salt, wherein the thrombin does not activate the fibrinogen during processing;
- and
- b) subjecting the fibrous pulp to a paper-making process to form a paper product.
A method for inhibiting or stopping blood loss from a wound comprising contacting the wound with a solid, biodegradeable hemostatic composition comprising a bioabsorbable polymer and a hemostatic compound for a period of time sufficient to promote blood clotting to occur, said hemostatic compound being prepared by combining, in a non-aqueous solvent, thrombin, fibrinogen and a calcium salt, wherein said fibrinogen is not activated by thrombin during processing.
Dependencies are inferred from the claim text.