System for freeze granulation
AssigneeIntegrated Biosystems, Inc.
InventorRichard Wisniewski
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Abstract
The present invention is a system and method for freeze granulation of a medium such as a biopharmeceutical product. The medium is put into a chamber and mixed using a pair of counter rotating agitators. The agitators have angled blades or paddles on them in order to induce motion in the medium parallel to the axis of the agitator shafts. A set of liquid nitrogen and liquid carbon dioxide nozzles are attached to the chamber. The liquid nitrogen nozzles spray a mist of liquid nitrogen into the medium. The liquid carbon dioxide nozzles spray carbon dioxide snow into the chamber. The liquid nitrogen and the carbon dioxide can be sprayed into the chamber at the same time or alternately.
Claims64
A freezing granulator system for use in cryopreservation of a medium, comprising:
- a chamber;
- a mixer, the mixer being housed within the chamber and coupled to the chamber;
- the chamber having a first input port for inputting carbon dioxide snow into the chamber;
- the chamber having a second input port for inputting a mist of liquid nitrogen droplets into the chamber;
- the chamber having a third input port for inputting the media;
- the chamber having an exhaust line for venting exhaust gasses;
- and
- the chamber having a output port for outputting the media.
Dependencies are inferred from the claim text.