Nasal administration of drugs

A method for intranasal administration of insulin with reduced nasal irritation which comprises administering a composition consisting essentially of a pharmaceutically effective amount of insulin, polysorbate-80 and nonoxynol-9 at a pH of between 6.8 to 7.2, and wherein the polysorbate-80 is at a concentration of between 0.01 to 0.5% by weight and the nonoxynol-9 is at a concentration of between 0.05 to 0.9% by weight.