Method and system for growing molluscum contagiosum in xenografts to immunocompromised hosts
AssigneeDavid A. Paslin
InventorDavid A. Paslin
Life of this patent
Estimating the term…
Abstract
A method and system is provided for the growth of the molluscum contagiosum virus in human skin xenografted to an immunocompromised host. A human skin graft is infected with molluscum contagiosum virus attached to or beneath a skin section of the immunocompromised host. According to the method, a section of skin of an immunocompromised host is prepared for receiving a human skin xenograft which is then placed onto or into the host. The human skin is infected with the molluscum contagiosum virus. The animals are monitored and the newly grown virus and its products are harvested for further study.
Claims23
A method for growing molluscum contaglosum virus (MCV) in human keratinocytes comprising:
- preparing a xenograft of human epithelial tissue;
- grafting the xenograft onto or into an immunocompromised host;
- infecting the xenograft with MCV either before or after grafting the xenograft onto or into the immunocompromised host;
- wherein the infection results in productive MCV replication and the production of progeny virus.
A system for expressing molluscum contaglosum virus (MCV) comprising:
- a xenograft of human epithelial tissue infected with MCV grafted onto or into an immunocompromised host such that the infection results in productive MCV replication and the production of progeny virus.
Dependencies are inferred from the claim text.