Mercapto alkyl peptidyl compounds having MMP and TNF inhibitory activity

A compound of general formula (I):

• ##STR9## wherein:
• R.sup.1 is selected from the group consisting of C.sub.1-6 alkyl, C.sub.2-6 alkenyl, (C.sub.1-6 alkyl)aryl, aryl, and C.sub.1-6 alkyl-AR.sup.9 where A is selected from the group consisting of O, NR.sup.9, and S(O).sub.m where m=0-2, and R.sup.9 is selected from the group consisting of H, C.sub.1-4 alkyl aryl, and (C.sub.1-4 alkyl)aryl;
• if A=NR.sup.9 the R.sup.9 groups may be the same or different;
• R.sup.2 is selected from the group consisting of hydrogen and C.sub.1-6 alkyl;
• R.sup.3 is selected from the group consisting of C.sub.1-6 alkyl-R.sup.6, aryl-R.sup.6, cyclo(C.sub.3-6)alkyl-R.sup.6, C.sub.1-6 alkyl-aryl-R.sup.6, and C.sub.1-6 alkyl-cyclo (C.sub.3-6) alkyl-R.sup.6, and R.sup.6 is an amidino or guanidino group;
• X is NR.sup.4 R.sup.5 where R.sup.4 is selected from the group consisting of hydrogen, aryl, cyclo(C.sub.3-6)alkyl, and C.sub.1-6 alkyl-cyclo(C.sub.3-6)alkyl;
• and R.sup.5 is hydrogen or C.sub.1-6 alkyl;
• or NR.sup.4 R.sup.5 is a ring;
• R.sup.7 is hydrogen or R.sup.10 CO where R.sup.10 is selected from the group consisting of C.sub.1-4 alkyl, C.sub.1-4 alkylaryl, cyclo(C.sub.3-6)alkyl, C.sub.1-4 alkyl-cyclo(C.sub.3-6)alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkenyl-aryl, and aryl;
• R.sup.8 is C.sub.1-4 alkyl-R.sup.11 ;
• R.sup.11 is phthalimido;
• R.sup.12 is hydrogen or is selected from the group consisting of COR.sup.9, CO.sub.2 R.sup.9 (where R.sup.9 is not H), CONHR.sup.9, and SO.sub.2 R.sup.9 (where R.sup.9 is not H);
• and
• R.sup.13 is selected from the group consisting of OH, OC.sub.1-4 alkyl, aryl, and C.sub.1-4 alkylaryl;
• or a salt, solvate, or hydrate thereof.