US 5,858,787 A · DNA encoding PACAP receptor protein and method for preparing said protein

Abstract

This invention discloses a PACAP receptor protein or a salt thereof, a DNA comprising a DNA fragment coding for the protein, a method for preparing the protein, antibody against the protein and use of the protein, DNA and antibodies. A PACAP receptor protein was purified from the bovine cerebrum. DNAs coding for PACAP receptor proteins were isolated from bovine, rat and human cDNA libraries, and their nucleotide sequences were determined. The PACAP receptor proteins and the DNAs coding for the proteins of the present invention can be used for (1) acquisition of antibodies and antisera, (2) construction of expression systems of recombinant receptor proteins, (3) development of receptor binding assay systems using said expression systems and screening of potential compounds for drugs, (4) execution of drug design based on the comparison of ligands and receptors which are structurally similar to each other, (5) preparation of probes and PCR primers in gene diagnosis, and the like.

Claims6

Dependent claims

An isolated DNA coding for a receptor protein capable of binding a pituitary adenylate cyclase activating protein, wherein the receptor protein comprises the amino acid sequence of SEQ ID NO:

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11 more elements

Dependencies are inferred from the claim text.

DNA encoding PACAP receptor protein and method for preparing said protein

Life of this patent

DNA encoding PACAP receptor protein and method for preparing said protein

Life of this patent

Abstract

Claims6