Adeno-associated virus materials and methods
AssigneeChildren's Hospital, Inc.
InventorPhilip R. Johnson
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Abstract
The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV) genomes, methods for packaging rAAV genomes, stable host cell lines producing rAAV and methods for delivering genes of interest to cells utilizing the rAAV. Particularly disclosed are rAAV useful in generating immunity to human immunodeficiency virus-1 and in therapeutic gene delivery for treatment of neurological disorders.
Claims4
A DNA vector comprising a recombinant adeno-associated virus genome and DNA sequences encoding adeno-associated rep/cap proteins, wherein said recombinant adeno-associated virus genome comprises adeno-associated virus inverted terminal repeats flanking non-adeno-associated virus DNA sequences operably linked to promoter and polyadenylation sequences and wherein said DNA sequences encoding rep/cap proteins are located outside said genome.
Dependencies are inferred from the claim text.