Vaccine against viruses associated with antibody-dependent-enhancement of viral infectivity
AssigneeAkzo Nobel N.V.
InventorsNicolaas Visser, Petrus Alphonsus Maria van Woensel, Thomas Christoph Mettenleiter
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Abstract
The present invention relates to a vaccine against a virus associated with antibody-dependent-enhancement of viral infectivity. Such a vaccine comprises a herpesvirus vector which is able to spread from cell-to-cell and which does produce non-infectious progeny virions having a gene encoding an antigen of said virus inserted into the herpesvirus genome.
Claims6
A vector comprising a live pseudorabies virus, Which is able to spread from cell-to-cell in a non-complementing cell culture and which produces non-infectious progeny virions, wherein the vector harbors a gene encoding an antigen of a virus associated with antibody-dependent enhancement (ADE) of viral infectivity, wherein said virus is selected from the group consisting of FIPV, PRRSV, EAV, African Swine Fever virus, FIV and HIV.
Dependencies are inferred from the claim text.