Staphylococcus aureus B-linked hexosamine antigen
AssigneeNabi
InventorsAli Ibrahim Fattom, Atulkumar Induprasad Patel
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Abstract
A negatively-charged S. aureus antigen contains .beta.-hexosamine as a major carbohydrate component. S. aureus strains that carry the antigen account for nearly all of the clinically significant strains of S. aureus that are not Type 5 or Type 8 strains. The antigen can be used in combination with S. aureus Type 5 polysaccharide antigen and S. aureus Type 8 polysaccharide antigen to provide nearly 100% coverage of S. aureus infection.
Claims23
An isolated Staphylococcus aureus antigen that comprises .beta.-linked hexosamine, wherein said antigen contains no O-acetyl groups detectable by nuclear magnetic resonance spectroscopy and specifically binds with antibodies to Staphylococcus aureus Type 336 deposited under ATCC 55804.
A composition comprising:
- an isolated S. aureus antigen that comprises .beta.-linked hexosamine, wherein said antigen contains no O-acetyl groups detectable by nuclear magnetic resonance spectroscopy and specifically binds with antibodies to Staphylococcus aureus Type 336 deposited under ATCC 55804;
- S. at least aureus Type 5 polysaccharide antigen or S. aureus Type 8 polysaccharide antigen;
- and a sterile pharmaceutically acceptable carrier therefor.
Dependencies are inferred from the claim text.