US 5,760,100 A · Extended wear ophthalmic lens

Extended wear ophthalmic lens

AssigneesCIBA Vision Corporation, Commonwealth Scientific and Industrial Research Organisation

InventorsPaul Clement Nicolson, Richard Carlton Baron, Peter Chabrecek, John Court, Angelika Domschke, Hans Jorg Griesser, Arthur Ho, Jens Hopken, Bronwyn Glenice Laycock, Qin Liu, Dieter Lohmann, Gordon Francis Meijs, Eric Papaspiliotopoulos, Judy Smith Riffle, Klaus Schindhelm, Deborah Sweeney, Wilson Leonard Terry, Jr., Jurgen Vogt, Lynn Cook Winterton

Life of this patent

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Abstract

An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

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Drawings

Claims48

Dependent claims

An ophthalmic lens having ophthalnically compatible inner and outer surfaces, said lens being suited to extended periods of wear in continuous, intimate contact with ocular tissue and ocular fluids, said lens comprising a polymeric material which has a high oxygen permeability and a high ion permeability, said polymeric material being formed from polymerizable materials comprising:

(a) at least one oxyperm polymerizable material and
(b) at least one ionoperm polymerizable material,
wherein said lens allows oxygen permeation in an amount sufficient to maintain corneal health and wearer comfort during a period of extended, continuous contact with ocular tissue and ocular fluids,
wherein said oxyperm polymerizablea material forms a phase or phases substantially seperate from the phase or phases formed by said ionoperm polymerizable material,
wherein said lens allows ion or water permeation via ion or water pathways in an amount sufficient to enable the lens to move on the eye such that corneal health is not substantially hared and wearer comfort is acceptable during a period of extended, continuous contact with ocular tissue and ocular fluids,
wherein said ionoperm polyrnerizable material, if polymerized alone would form a hydrophilic polymer having a water content of atleast 10 weight percent upon full hydration, and
wherein said ophthalmic lens has an oxygen transmissibility of at least about 70 barrers/mm and an ion permeability characteized either by (1) an Ionoton Ion Permeability Coefficient of greater than about 0.2.times.10.sup.-6 cm.sup.2 /sec. or(2) an Ionoflux Diffusion Coefficient of greater than about 1.5.times.10.sup.31 6 mm.sup.2 /min. wherein said ion permeability is measured with respect to sodium ions.

4 more elements

An ophthalmic lens having ophthalmically compatible inner and outer surfaces, said lens being suited to extended periods of wear in continuous, intimate contact with ocular tissue and ocular fluids, said lens comprising a polymeric material which has a high oxygen permeability and a high ion permeability, said polymeric material being formed from polymerizable materials comprising at least one polymerizable material comprising:

(a) at least one oxyperm segment;
and
(b) at least one ionoperm segment,
wherein said lens allows oxygen permeation in an amount sufficient to maintain corneal health and wearer comfort during a period of extended, continuous contact with ocular tissue and ocular fluids,
wherein said oxyperm polymerizable mateerial forms a phase or phases substantially separate from the phase of phase formed by said ionoperm polymerizable material,
wherein said lens allows ion or water permeation via ion or water pathways in an amount sufficient to enable the lens to move on the eye such that corneal health is not substantially harmed and wearer comfort is acceptable during a period of extended, continuous contact with ocular tissue and ocular fluids,
Wherein said ionoperm polymerizable material, if polymerized alone, would form a hydrophilic polymer having a water content of at least 10 weight percent upon full hydration, and
Wherein said ophthalmic lens has an oxygen transmissibility of at least about 70 barrers/mm and an ion permeability characterized either by (1) an Ionoton Ion Permeability Coeffecient of greater than about0.2.times.10.sup.31 6 cm.sup.2 /sec. or (2) an Ionoflux Diffusion Coefficient of greater than about 1.5.times.10.sup.-6 mm.sup.2 min. Wherein said ion permeability is measured with respect to sodiumn ions.

5 more elements

Dependencies are inferred from the claim text.

Description31,809 words

Summary21,925 words

#1. Field of the Invention

#This invention relates broadly to lenses and polymeric materials useful in optic and ophthalmic arts. More specifically, this invention relates to polymeric materials and treatment processes useful in the manufacture of contact lenses. Still more specifically, this invention relates to contact lenses useful as extended-wear contact lenses.

#2. Description of the Related Art

Detailed description9,884 words

#The previous disclosure will enable one having ordinary skill in the art to practice the invention. In order to better enable the reader to understand specific embodiments and the advantages thereof, reference to the following examples is suggested. However, the following examples should not be read to limit the scope of the invention.

#Examples A-D are arranged in accordance with the materials defined above. Thus, Examples A-1, A-2, etc. relate to Material "A" as defined above, Examples B-1, B-2, etc. relate to Material "B" as defined above, Examples C-1, C-2, etc. relate to Material "C", and Examples D- 1, D-2, etc. relate to Material "D". Temperatures are stated in degrees Celsius unless otherwise specified.

#Examples E, F and G are directed to demonstrating a correlation between on-eye movement and the Ionoton Ion Permeability Coefficient, the Ionoflux Ion Permeability Coefficient, and the Hydrodell Water Permeability Coefficient, respectively.

Facts

Application

08/569,816Filed 8 Dec 1995 · continuation in part

Priority

DE 95810221.24 Apr 1995

Granted

2 Jun 1998

Term ended

6 Sep 2014

Estimated · how

20 years from earliest known nonprovisional domestic filing. Maintenance-fee lapses, terminal disclaimers and statutory extensions have not been checked. The continuity chain may be incomplete; this is not an enforceability determination. Patent term adjustment is unavailable; no adjustment was added.

Classification29 codes

G02C 7/049
Contact lenses for the eyes: contact lenses having special fitting or structural features achieved by special materials or material structures
A61L 27/26
Macromolecular materials: mixtures of macromolecular compounds
A61L 27/34
Materials for coating prostheses: macromolecular materials
B05D 1/62
Processes for applying liquids or other fluent materials: plasma-deposition of organic layers