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US 5,753,260 AGranted
Vaccines against sterols
AssigneeEntreMed, Inc.
InventorsCarl R. Alving, Julie Kenner, Glenn M. Swartz, Jr., John W. Madsen
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AssigneeEntreMed, Inc.
InventorsCarl R. Alving, Julie Kenner, Glenn M. Swartz, Jr., John W. Madsen
Estimating the term…
The present invention relates to immunoreactive compositions and methods for immunizing humans or animals against sterols, such as cholesterol and its derivatives, and their use in methods for reducing the serum cholesterol levels of the immunized individuals and to retard or reduce the severity of atherosclerosis or atherosclerosis plaques caused by ingestion of dietary cholesterol. Another embodiment of the present invention encompasses ergosterol or ergosterol derivative compositions useful for the treatment or prevention of fungal infection, and methods of use thereof. Yet another aspect of the invention is dairy products containing anti-ergosterol antibodies produced by dairy animals immunized against ergosterol according to the present invention and methods of making thereof. A further aspect of the invention is a diagnostic assay for determining whether a human or animal has a fungal infection.
A vaccine comprising a liposome comprising between about 55.5 mol % and 71 mol % cholesterol, and either phosphatidyl choline or dimyristoyl phosphatidyl choline, for immunizing or hyperimmunizing a mammal against cholesterol.
A therapeutic method for vaccinating a mammal against cholesterol to treat or prevent hypercholesterolemia or atherosclerosis comprising, administering to the mammal an amount effective to immunize the mammal against cholesterol of a vaccine comprising a liposome comprising between about 43 mol % and 71 mol % cholesterol, and either phosphatidyl choline or dimyristoyl phosphatidyl choline.
Dependencies are inferred from the claim text.