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US 5,753,235 AGranted
Recombinant canine herpesviruses
AssigneeHeska Corporation
InventorsElizabeth J. Haanes, Rexann S. Frank
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AssigneeHeska Corporation
InventorsElizabeth J. Haanes, Rexann S. Frank
Estimating the term…
The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid molecules. The present invention also relates to the use of such genomes and viruses in a variety of applications, including as therapeutic compositions to protect animals from disease. The present invention also relates to novel isolated CHV nucleic acid molecules, to CHV proteins encoded by such nucleic acid molecules, and to antibodies raised against such CHV proteins as well as to the use of such CHV nucleic acid molecules, proteins and antibodies as therapeutic compositions to protect an animal from CHV. The present invention also includes constructs comprising CHV nucleic acid molecules that include heterologous nucleic acid molecules, to recombinant vectors including such constructs, and to the use of such constructs and vectors in the production of recombinant CHV and recombinant CHV genomes.
An isolated canine herpesvirus (CHV) nucleic acid molecule that hybridizes under stringent hybridization conditions with a CHV nucleic acid region selected from the group consisting of a CdUPTase gene, a CgE gene, a CgG gene, a CgI gene, a CPK gene, a CTK gene, a CIR6 gene, a CUS2 gene, a CUS9 gene, a CUL49 gene, a CUL51 gene, a CUL48 gene, a CUL52 gene and a region of the CHV genome spanning from the 3' end of the coding region of the CUL41 gene through the 3' end of the coding region of the CUL38 gene.
A recombinant virus comprising an isolated CHV nucleic acid region selected from the group consisting of a CdUTPase gene, a CgE gene, a CgG gene, a CgI gene, a CPK gene, a CTK gene, a CIR6 gene, a CUS2 gene, a CUS9 gene, a CUL49 gene, a CUL51 gene, a CUL48 gene, a CUL52 gene and a region of the CHV genome spanning from the 3' end of the coding region of the CUL41 gene through the 3' end of the coding region of the CUL38 gene and portions thereof, wherein a portion encodes an epitope that elicits an immune response against a CHV protein.
A recombinant vector comprising an isolated CHV nucleic acid region selected from the group consisting of a CdUTPase gene, a CgE gene, a CgG gene, a CgI gene, a CPK gene, a CTK gene, a CIR6 gene, a CUS2 gene, a CUS9 gene, a CUL49 gene, a CUL51 gene, a CUL48 gene, a CUL52 gene and a region of the CHV genome spanning from the 3' end of the coding region of the CUL41 gene through the 3' end of the coding region of the CUL38 gene and portions thereof, wherein the portion forms a stable hybrid with the complementary sequence of one of said regions.
A recombinant CHV comprising a recombinant CHV genome, said CHV genome comprising a heterologous nucleic acid molecule operatively linked to a transcription control region, said heterologous nucleic acid molecule being in a region of said CHV genome selected from the group consisting of a nonessential gene of said CHV genome and an intergenic region of said CHV genome, said CHV being reproduction competent.
A recombinant CHV genome comprising a heterologous nucleic acid molecule operatively linked to a transcription control region said heterologous nucleic acid molecule being in a region of said CHV genome selected from the group consisting of a nonessential gene of said CHV genome and an intergenic region of said CHV genome, said CHV genome is reproduction competent.
A composition for delivery to a canid, said composition comprising a recombinant CHV comprising a recombinant CHV genome, said CHV genome comprising a heterologous nucleic acid molecule operatively linked to a transcription control region, said heterologous nucleic acid molecule being in a region of said CHV genome selected from the group consisting of a nonessential gene of said CHV genome and an intergenic region of said CHV genome, said CHV being reproduction competent.
A composition for delivery to a canid, said composition comprising a recombinant CHV genome, said CHV genome comprising a recombinant CHV genome, said CHV genome comprising a heterologous nucleic acid molecule operatively linked to a transcription control region, said heterologous nucleic acid molecule being in a region of said CHV genome selected from the group consisting of a nonessential gene of said CHV genome and an intergenic region of said CHV genome, wherein a recombinant CHV comprising said CHV genome is reproduction competent.
A method to deliver a compound to a canid, said method comprising administering to said canid a composition comprising a recombinant CHV comprising a recombinant CHV genome, said CHV genome comprising a heterologous nucleic acid molecule encoding said compound, operatively linked to a transcription control region, said heterologous nucleic acid molecule being in a region of said CHV genome selected from the group consisting of a nonessential gene of said CHV genome and an intergenic region of said CHV genome, said CHV being reproduction competent.
A method to deliver a compound to a canid, said method comprising administering to said canid a composition comprising a recombinant CHV genome, said CHV genome comprising a heterologous nucleic acid molecule encoding said compound, operatively linked to a transcription control region, said heterologous nucleic acid molecule being in a region of said CHV genome selected from the group consisting of a nonessential gene of said CHV genome and an intergenic region of said CHV genome, wherein a recombinant CHV comprising said CHV genome is reproduction competent.
Dependencies are inferred from the claim text.