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US 5,710,293 AGranted
Method of preparation of ester derivatives of steroids
AssigneeThe Population Council, Center for Biomedical Research
InventorFang Li
Life of this patent
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Abstract
The present invention relates to a method of using a perchloric acid catalyzed reaction to make acyl derivatives of norprogesterone compounds and, in particular, 16-methylene-17.alpha.-hydroxy-19-norpregn-4-ene-3,20-dione.
Claims22
A method of synthesizing acylated derivative of norprogesterone compounds comprising the steps of:
- providing a norprogesterone compound having the tetracyclic ring system of asteroid substituted in the 16th position with an exomethylene group and having a hydroxyl group in the 17.alpha. position;
- and reacting said norprogesterone compound with at least one acylating agent in the presence of perchloric acid, so as to form a reaction mixture containing the corresponding ester derivative of said norprogesterone compound.
A method of synthesizing acylated derivatives of 16-methylene-17.alpha.-hydroxy-19-norpregn-4-ene-3,20-dione comprising the steps of:
- providing , a 16-methylene-17.alpha.-hydroxy-19-norpregn-4-ene-3,20-dione;
- and
- reacting said 16-methylene-17.alpha.-hydroxy-19-norpregn-4-ene-3,20-dione with at least a stoichiometric amount of at least one acylating compound selected from the group consisting an anhydride and an acyl halide in the presence of perchloric acid at room temperature so as to form the corresponding acyl derivative thereof.
Dependencies are inferred from the claim text.