Methadone derivatives and protein and polypeptide methadone derivative conjugates and labels
AssigneeBiosite Diagnostics, Inc.
InventorKenneth F. Buechler
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Abstract
The present invention is directed to novel methadone derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to methadone and methadone metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.
Claims6
Compounds of the formula:
- ##STR27## where R is a linking group selected from the group consisting of:
- ##STR28## where A is a linking group of from 1 to 20 carbons and from 0 to 10 heteroatoms, either branched or straight chain, wherein said heteroatoms are selected from the group consisting of NH, O and S.
A compound of the formula:
- ##STR29## where P is an antigenic protein or polypeptide or a protein, polypeptide or label;
- where x is at least one and not greater than 100;
- where R is a linking group selected from the group consisting of:
- ##STR30## where A is a linking group of from 1 to 20 carbons and 0 to 10 heteroatoms either branched or straight chain, wherein said heteroatoms are selected from the group consisting of NH, O and S;
- where B is a linking group attached to a protein, polypeptide or label, wherein B is selected from the group consisting of;
- ##STR31## where Z is a linking group of from 1 to 20 carbons and 0 to 10 heteroatoms and may be branched or straight chain, wherein said heteroatoms are selected from the group consisting of NH, O and S.
Compounds of formula:
- ##STR32## Where R is a linking group selected from the group consisting of:
- ##STR33##
A compound of the formula:
- ##STR34## where P is an antigenic protein or polypeptide or a protein, polypeptide or label;
- where x is at least one and not greater than 100;
- where Z is a linking group of from 1 to 20 carbons and 0 to 10 heteroatoms and may be branched or straight chain, wherein said heteroatoms are selected from the group consisting of NH, O and S.
Dependencies are inferred from the claim text.