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AssigneeThe Green Cross Corporation
InventorsWataru Ohtani, Naoto Furuhata, Akinori Sumi, Munehiro Noda, Takao Ohmura
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A method for decoloring a recombinant human serum albumin by treating the albumin with a reducing agent is disclosed. Also, a method for decoloring a recombinant human serum albumin by treating the albumin with a method removing free polysaccharides with a cation exchanger followed by heat treatment is disclosed. The present invention provides a recombinant human serum albumin, coloring of which is fully suppressed by preventing binding of certain coloring components, which are contained in the raw materials or contaminants secreted by a microorganism, to human serum albumin so as not to cause coloring of the human serum albumin.
A method for decoloring a recombinant human serum albumin, which comprises treating a recombinant human serum albumin (HSA), during purification thereof except in a heat treatment, with a reducing agent, thereby decoloring the recombinant HSA.
A method for decoloring a recombinant human serum albumin (HSA), which comprises removing free polysaccharides from a recombinant human serum albumin and then heat treating said albumin in the presence of a reducing agent, thereby decoloring the recombinant HSA.
A method for decoloring a recombinant human serum albumin, which comprises treating a recombinant human serum albumin (HSA) with a cation exchanger to remove free polysaccharides therefrom and then heat treating said albumin in the presence of a reducing agent, thereby decoloring the recombinant HSA.
Dependencies are inferred from the claim text.