Phenethylamine compounds
AssigneeSmithKline Beecham Corporation
InventorsSiegfried Christensen, IV, Cornelia Jutta Forster
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Abstract
Substituted phenethylamines of formula (I) useful for treating phosphodiesterase IV related ##STR1## disease states are disclosed herein.
Claims3
A compound of formula I ##STR8## or a salt thereof, where Q is a radical of formula ##STR9## R.sub.1 is C.sub.7-11 polycycloalkyl, C.sub.3-6 cycloalkyl wherein the cycloalkyl moieties are unsubstituted or substituted by 1 to 3 methyl groups or one ethyl group;
- R.sub.2 is --CH.sub.3 or --CH.sub.2 CH.sub.3 unsubstituted or substituted by 1 or more halogens:
- R.sub.3 is lower alkyl unsubstituted or substituted by one or more halogens, --CR.sub.4 R.sub.5 OR.sub.4 or --CR.sub.4 (OR.sub.4)CR.sub.4 R.sub.5 OR.sub.4 ;
- R.sub.4 and R.sub.5 are independently hydrogen, methyl or ethyl;
- R.sub.6 is hydrogen, halogen, --C.sub.1-4 alkyl, halo-substituted C.sub.1-4 alkyl, --CH.dbd.CR.sub.4 R.sub.5, cyclopropyl unsubstituted or substituted by R.sub.4, or --C.tbd.CR.sub.4 ;
- R.sub.7 is hydrogen, F, or --CH.sub.3 unsubstituted or substituted by 1 to 3 fluoro groups;
- R.sub.8 is H, F, or C.sub.1-2 alkyl optionally substituted by 1 or more fluoro groups;
- R.sub.9 is H or unsubstituted or substituted C.sub.1-6 alkyl, wherein optional substituents are from one to three groups independently selected from the group consisting of --CH.sub.3 or --CH.sub.2 CH.sub.3 unsubstituted or substituted by 1 or more halogens;
- X.sub.1 is YR.sub.2,
- X.sub.2 is O;
- X.sub.3 is hydrogen, halogen or X.sub.1 ;
- Y is O, S, SO or SO.sub.2 ;
- Z is O.
A method for treating allergic and inflammatory diseases which comprises administering to a mammal in need thereof an effective amount of a compound of Formula I either alone or in admixture with a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.