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US 5,708,187 AGranted
6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT.sub.1F agonists
AssigneeEli Lilly and Company
InventorsMichael Edward Flaugh, Anton Daniel Kiefer, Jr., Clint Duane Walker, Yao-Chang Xu
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Abstract
This invention provides novel 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta7,6-b!indoles. These compounds are 5-HT.sub.1F agonists which are useful for the treatment of migraine and associated disorders.
Claims11
A compound of formula:
- ##STR26## wherein:
- R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1 -C.sub.4 alkyl,or --CH.sub.2 CH.sub.2 -Aryl where Aryl is phenyl, phenyl monosubstituted with halo, or 1-(C.sub.1 -C.sub.6 alkyl)pyrazol-4-yl;
- X is --NHC(O)R.sup.3, --NHC(Y)NHR.sup.4, --NHC(O)OR.sup.5, or --NHSO.sub.2 R.sub.7 ;
- R.sup.3 is C.sub.2 -C.sub.6 alkenyl, C.sub.3 -C.sub.8 cycloalkyl, phenyl, substituted phenyl, naphthyl, (C.sub.1 -C.sub.4 alkylene)-phenyl, thienylmethyl, or a heterocycle;
- R.sup.4 is C.sub.1 -C.sub.6 alkyl, phenyl, or phenyl disubstituted with halo;
- R.sup.5 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, benzyl or phenyl monosubstituted with halo;
- R.sup.6 is C.sub.1 -C.sub.6 alkyl, phenyl, or phenyl monosubstituted with halo or C.sub.1 -C.sub.4 alkoxy;
- R.sup.7 is dimethylamino, phenyl or phenyl monosubstituted with halo or C.sub.1 -C.sub.4 alkyl;
- m is 0 or 1;
- n is 1 or 2;
- and
- Y is S or O;
- and pharmaceutically acceptable salts and hydrates thereof.
10 more elements
Dependencies are inferred from the claim text.