Cephalostatin analogues
AssigneeSchering Corporation
InventorsEkkehard Winterfeldt, Andreas Kramer, Ulrike Ullmann, Henry Laurent
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Abstract
Synthetically produced cephalostatin analogues of the formula I described in the disclosure, synthetic methods for preparing the cephalostatin analogues, pharmaceutical compositions containing the analogues and methods for using the analogues as active agent in pharmaceutical uses, particularly due to their cytotoxic activity.
Claims12
A cephalostatin analogue of formula I, ##STR14## in which a) A and A' each stand for an alkanoyloxy group R--CO--O-- with R as a straight-chain or branched-chain C.sub.1 to C.sub.7 alkyl radical, and B and D as well as B' and D' each together stand for an additional C--C bond, or
- b) A' stands for an alkanoyloxy group R--CO--O-- with R as a straight-chain or branched-chain C.sub.1 to C.sub.7 alkyl radical, and B' and D' together stand for an additional C--C bond, and A and B together stand for a keto-oxygen atom and D stands for a hydrogen atom, or
- c) A stands for a .beta.-position hydroxy group, and B as well as D each stand for a hydrogen atom, and A' and B' together stand for a keto-oxygen atom, and D' stands for a hydrogen atom or
- d) A and A' each stand for a .beta.-position hydroxy group, and B, D, B' and D' each stand for a hydrogen atom.
An intermediate compound of formula IV ##STR22##
Dependencies are inferred from the claim text.