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US 5,708,157 AGranted
Secreted proteins and polynucleotides encoding them
AssigneeGenetics Institute, Inc.
InventorsKenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Cheryl Evans, Vikki Spaulding
Life of this patent
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Abstract
Novel polynucleotides and the proteins encoded thereby are disclosed.
Claims21
An isolated polynucleotide selected from the group consisting of:
- (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1;
- (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 218 to nucleotide 628;
- (c) a polynucleotide comprising the nucleotide sequence of the full length protein coding sequence of clone AJ26.sub.-- 3 deposited under accession number ATCC 98115;
- (d) a polynucleolide encoding the full length protein encoded by the cDNA insert of clone AJ26.sub.-- 3 deposited under accession number ATCC 98115;
- (e) a polynucleotide comprising the nucleotide sequence of the mature protein coding sequence of clone AJ26.sub.-- 3 deposited under accession number ATCC 98115;
- (f) a polynucleotide encoding the mature protein encoded by the cDNA insert of clone AJ26.sub.-- 3 deposited under accession number ATCC 98115;
- (g) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:2, said sequence of SEQ ID NO:2 being the sequence encoded by the cDNA insert of clone AJ26.sub.-- 3 deposited under accession number ATCC 98115;
- (h) a polynucleotide which is an allelic variant of a polynucleotide of (a)-(f) above;
- and
- (i) a polynucleotide capable of hybridizing under conditions of incubation at 65.degree. C. in 6.times.SSC/0.5% SDS, followed by washing with 2.times.SSC/0.5% SDS at room temperature, with a polynucleotide consisting of the nucleotide sequence of SEQ ID NO:1 from nucleotide 218 to nucleotide 628.
7 more elements
An isolated protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of SEQ ID NO:2, said sequence of SEQ ID NO:2 being the sequence encoded by the cDNA insert of clone AJ26.sub.-- 3 deposited under accession number ATCC 98115;
- (b) the amino acid sequence of SEQ ID NO:2 from amino acid 27 to amino acid 82;
- and
- (c) the amino acid sequence encoded by the cDNA insert of clone AJ26.sub.-- 3 deposited under accession number ATCC 98115;
- the protein being substantially free from other mammalian proteins.
2 more elements
An isolated gene corresponding to the cDNA sequence of SEQ ID NO:1 and SEQ ID NO:3.
Dependencies are inferred from the claim text.