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US 5,708,155 AGranted
Enhanced immunogenicity using leukotoxin chimeras
AssigneeUniversity of Saskatchewan
InventorsAndrew A. Potter, Mark J. Redmond, Huw P. A. Hughes
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Abstract
New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected antigen. The leukotoxin functions to increase the immunogenicity of the antigen fused thereto.
Claims19
A DNA construct encoding a chimeric protein, said DNA construct comprising a first nucleotide sequence encoding a leukotoxin polypeptide capable of activating helper T-cells directed to a selected antigen, operably linked to a second nucleotide sequence encoding said selected antigen.
Dependencies are inferred from the claim text.