US 5,708,142 A · Tumor necrosis factor receptor-associated factors

Abstract

The invention concerns new tumor necrosis factor receptor associated factors, designated TRAF. The new factors are capable of specific association with the intracellular domain of the type 2 TNF receptor (TNF-R2), and are involved in the mediation of TNF biological activities,

Claims1

Dependent claims

An isolated TRAF selected from the group consisting of TRAF1 having the amino acid sequence depicted in SEQ. ID. NO:2 and TRAF2 having the amino acid sequence depicted in SEQ. ID. NO:4.

Dependencies are inferred from the claim text.

Facts

Application

08/250,858Filed 27 May 1994

Granted

13 Jan 1998

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

C12Q 1/6897
Involving nucleic acids: involving reporter genes operably linked to promoters
C07K 14/7151
For cytokines; for lymphokines; for interferons: for tumor necrosis factor [TNF], for lymphotoxin [LT]
C07K 16/2878
Against receptors, cell surface antigens or cell surface determinants: against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
C12Q
Measuring or testing processes involving enzymes, nucleic acids or microorganisms

Tumor necrosis factor receptor-associated factors

Life of this patent

Abstract

Claims1

Tumor necrosis factor receptor-associated factors

Life of this patent

Abstract

Claims1