Production of proteins using 7B2 protein
AssigneeCiba-Geigy Corporation
InventorsGerardus Julianus Maria Martens, Bhabatosh Chaudhuri, Christine Stephan
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Abstract
The invention lies in the field of genetic engineering and, in particular, is concerned with the use of 7B2 as chaperone in vivo or in vitro. The invention accordingly concerns a method for producing a desired protein in vivo with the aid of recombinant cells capable of expressing 7B2 and of expressing and secreting said desired protein. Another aspect is accordingly an in vitro method for the deaggregation or prevention of aggregation of protein by treating the protein with 7B2.
Claims8
A method for the deaggregation or prevention of aggregation of a monomeric protein in vitro, characterized in that the protein or aggregates thereof are treated with 7B2 in sufficient quantity and for sufficient time to result in a solution of essentially monomeric protein that is a bioactive protein.
Dependencies are inferred from the claim text.