Polypetides which bind to human MDM2
AssigneeThe Johns Hopkins University
InventorsMarilee Burrell, David E. Hill, Kenneth W. Kinzler, Bert Vogelstein
Life of this patent
Estimating the term…
Abstract
A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.
Claims13
A polypeptide consisting of a contiguous portion of p53, said portion comprising amino acids 13-41 of p53 as shown in SEQ ID NO:1, said polypeptide capable of binding to human MDM2.
Dependencies are inferred from the claim text.