Inhibitor of inflammatory cytokine formation comprising polyprenyl derivatives as the active ingredient
AssigneeSankyo Company, Limited
InventorAkikuni Yagita
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Abstract
Polyprenyl derivatives having the general formula as the active ingredient: ##STR1## where R.sup.1 and R.sup.2 are the same or different, and each represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.12 aliphatic acyl group, a C.sub.7 -C.sub.11 aromatic acyl group or a C.sub.8 -C.sub.12 aryl-substituted aliphatic acyl group; and n represents an integer from 0 to 2, show excellent activity in the inhibition of the formation of inflammatory cytokines, and they exhibit an excellent therapeutic effect on inflammatory bowel diseases such as ulcerative colitis, Crohn's disease and Behcet syndrome.
Claims17
A method for the prophylaxis or therapy of diseases which are amenable to the inhibition of inflammatory cytokine formation, said method comprising administering an effective amount, to a patient in need thereof, of a polyprenyl having the following formula, as the active ingredient:
- ##STR3## where R.sup.1 and R.sup.2 are the same or different, and each represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.12 aliphatic acyl group, a C.sub.7 -C.sub.11 aromatic acyl group or a C.sub.8 -C.sub.12 aryl-substituted aliphatic acyl group;
- and n represents an integer from 0 to 2.
A method for the prophylaxis or therapy of ulcerative colitis, comprising administering an effective amount, to a patient in need thereof, of a polyprenyl derivatives having the following formula, as the active ingredient:
- ##STR4## where R.sup.1 and R.sup.2 are the same or different, and each represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.12 aliphatic acyl group, a C.sub.7 -C.sub.11 aromatic acyl group or a C.sub.8 -C.sub.12 aryl-substituted aliphatic acyl group;
- and n represents an integer from 0 to 2.
Dependencies are inferred from the claim text.