Amide derivatives and their therapeutic use
AssigneeGlaxo Wellcome Inc.
InventorsJames Leroy Kelley, David Lee Musso
Life of this patent
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Abstract
A compound of formula (I), wherein R.sup.1 and R.sup.2 are independently selected from chloro, fluoro, bromo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or C.sub.1-6 haloalkyl provided that both R.sup.1 and R.sup.2 are not fluoro; R.sup.3 and R.sup.4 are independently selected from hydrogen and C.sub.1-6 alkyl, and pharmaceutically acceptable salts, solvates or physiologically functional derivatives thereof, their use in medicine, particularly the phrophylaxis or treatment of conditions associated with inflammation, arthritis, or pain, pharmaceutical compositions comprising them, and processes for their preparation are disclosed. ##STR1##
Claims9
A compound of the formula (I):
- ##STR13## wherein R.sup.1 and R.sup.2 are independently selected from chloro, fluoro, bromo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or C.sub.1-6 haloalkyl provided that both R.sup.1 and R.sup.2 are not fluoro;
- R.sup.3 and R.sup.4 are independently selected from hydrogen and (C.sub.1-6 alkyl;
- or a pharmaceutically acceptable salt, solvate, or ester thereof.
A compound of formula (1A) ##STR14## wherein R.sup.1a is chloro, R.sup.2a is chloro, fluoro, bromo or methyl, and R.sup.3 and R.sup.4 are independently selected from hydrogen, methyl and ethyl;
- or a pharmaceutically acceptable salt, solvate or ester thereof.
An intermediate selected from
- 2-(4-chloro-6-fluoro-1-hydroxy-1-indanyl)acetic acid
- (E)-2-(4-Chloro-6-fluoro-1-indanylidene)acetic acid
- (E)-2-(4-Chloro-6-fluoro-1-indanylidene)acetyl chloride
- 2-(4,6-Dichloro-1-hydroxy-1-indanyl)acetic acid
- (E)-(4,6-Dichloro-1-indanylidene)acetic acid
- (E)-2-(4,6-Dichloro-1-indanylidene)acetyl chloride
- 2-(6-Fluoro-1-hydroxy-4-methyl-1-indanyl)acetic acid
- (E)-2-(6-Fluoro-4-methyl-1-indanylidene)acetic acid
- (E)-2-(6-Fluoro-4-methyl-1-indanylidene)acetyl chloride
- 2-(6-Chloro-4-fluoro-1-hydroxy-1-indanyl)acetic acid
- (E)-2-(6-Chloro-4-fluoro-1-indanylidene)acetic acid
- (E)-2-(6-Chloro-4-fluoro-1-indanylidene)acetyl chloride
- 2-(4-Bromo-6-fluoro-1-hydroxy-1-indanylidene)acetic acid
- (E)-2-(4-Bromo-6-fluoro-1-indanylidene)acetic acid
- (E)-2-(4-Bromo-6-fluoro-1-indanyl)acetyl chloride
- 2-(4-Chloro-6-methyl-1-hydroxy-1-indanyl)acetic acid
- (E)-2-(4-Chloro-6-methyl-1-indanylidene)acetic acid and
- (E)-2-(4-Chloro-6-methyl-1-indanylidene)acetyl chloride.
Dependencies are inferred from the claim text.