Methods for promoting wound healing
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorDvorit Samid
Life of this patent
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Abstract
Compositions and methods of treating anemia, cancer, AIDS, or severe .beta.-chain hemoglobinopathies by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof or derivatives thereof alone or in combination or in conjunction with other therapeutic agents. Pharmacologically-acceptable salts alone or in combinations and methods of preventing AIDS and malignant conditions, and inducing cell differentiation are also aspects of this invention.
Claims36
A method of inducing the production of TGF.alpha. in a cell comprising contacting the cell with a TGF.alpha. inducing amount of a compound of the formula:
- ##STR3## wherein R.sub.0 is aryl, phenoxy, substituted aryl or substituted phenoxy;
- R.sub.1 and R.sub.2 are, independently, H, hydroxy, lower alkoxy, lower straight or branched chain alkyl or halogen;
- R.sub.3 and R.sub.4 are, independently, H, lower alkoxy, lower straight or branched chain alkyl or halogen;
- and
- n is an integer from 0 to 2;
- a salt thereof;
- a stereoisomer thereof;
- and a mixture thereof.
The method of wherein the compound is .alpha.-methylphenylacetic acid, .alpha.-ethylphenylacetic acid, .alpha.-hydroxyphenylacetic acid, .alpha.-methoxyphenylacetic acid, 1-naphthylacetic acid, 4-chlorophenylacetic acid, 4-iodophenylacetic acid, 4-fluorophenylacetic acid, 3-chlorophenylacetic acid, 2-chlorophenylacetic acid, 2,6-dichlorophenylacetic acid, 2-methylphenylacetic acid, 3-methylphenylacetic acid, 4-methylphenylacetic acid, phenoxypropionic acid, 4-chlorophenylbutyric acid, 4-iodophenylbutyric acid, 4-fluorophenylbutyric acid, 3-chlorophenylbutyric acid, or 2-chlorophenylbutyric acid.
A method of promoting the healing of a wound in a subject comprising administering to a wound in the subject a would healing mount of a compound of the formula:
- ##STR4## wherein R.sub.0 is aryl, phenoxy, substituted aryl or substituted phenoxy;
- R.sub.1 and R.sub.2 are, independently, H, hydroxy, lower alkoxy, lower straight or branched chain alkyl or halogen;
- R.sub.3 and R.sub.4 are, independently, H, lower alkoxy, lower straight or branched chain alkyl or halogen;
- and
- n is an integer from 0 to 2;
- a salt thereof;
- a stereoisomer thereof;
- and a mixture thereof.
Dependencies are inferred from the claim text.