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AssigneeAllergan, Inc.
InventorsMichael E. Garst, James E. Burke, Larry A. Wheeler
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A pharmaceutical composition, useful for treating animals of the mammalian species, including humans, to treat diseases and conditions which normally respond to treatment with alpha.sub.2 adrenergic agents, contains as its active alpha.sub.2 adrenergic agent ingredient one or more compounds of the formula ##STR1## where X is O, S or NH; n is an integer with the values of 0, 1 or 2; when n is 0 then R.sub.1 is lower alkyl having 1 to 6 carbon atoms and R.sub.2 is H or lower alkyl having 1 to 6 carbon atoms; when n is 1 or 2, then R.sub.1 and R.sub.2 both are methylene (CH.sub.2), or methylene substituted with an R.sub.5 group where R.sub.5 is lower alkyl of 1 to 6 carbons; R.sub.3 and R.sub.4 independently are H or lower alkyl having 1 to 6 carbons; R.sub.6 is H or lower alkyl of 1 to 6 carbons.
A method of treating diseases or conditions of an animal of the mammalian species, the disease or condition being of the type which responds to treatment with alpha.sub.2 adrenergic agents, the method of treatment comprising the steps of administering to the mammal a pharmaceutical composition which comprises as its active ingredient an effective amount of one or more compounds of the formula ##STR9## where X is S;
A method of treating animals of the mammalian species, which are afflicted with a disease or condition of the type which is treated with an .alpha..sub.2 adrenergic agent having effect of altering the rate of fluid flow in the gastrointestinal tract, or anti-spastic, anti-hypertensive, anti-ischemic, anti-epileptic, anesthetic, memory-enhancing or sleep aiding effect, or the effect of increasing fluid flow in at least one kidney, the method of treatment comprising the steps of administering to the mammal a pharmaceutical composition which comprises as its active ingredient an effective amount of one or more compounds of the formula ##STR10## where X is S;
Dependencies are inferred from the claim text.