5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-and 3-(piperidin-4-yl)-1H-indoles: new 5-HT.sub.1F agonists

A compound of Formula I:

• ##STR13## in which A--B is --CH--CH.sub.2 -- or --C.dbd.CH--;
• R is H or C.sub.1 -C.sub.6 alkyl;
• R.sup.1 is H or C.sub.1 -C.sub.4 alkyl;
• X is --C(O)NR.sup.4 R.sup.15, --NR.sup.5 R.sup.6, --NR.sup.7 SO.sub.2 R.sup.8, --NHC(Q)NR.sup.10 R.sup.11, --NHC(O)OR.sup.12 or --NR.sup.13 C(O)R.sup.14 ;
• where
• Q is O, or S;
• R.sup.4 is heteroaryl, substituted heteroaryl, heteroaryl(C.sub.1 -C.sub.4 alkyl), or substituted heteroaryl(C.sub.1 -C.sub.4 alkyl);
• R.sup.4 and R.sup.15 taken together with the nitrogen atom form a pyrrolidine, piperidine, substituted piperidine, piperazine, 4-substituted piperazine, morpholine or thiomorpholine ring;
• R.sup.5 and R.sup.6 are both trifluoromethanesulfonyl;
• R.sup.7 is H or C.sub.1 -C.sub.4 alkyl;
• R.sup.8 is phenyl, substituted phenyl, or di(C.sub.1 -C.sub.4 alkyl)amino;
• R.sup.10 and R.sup.11 are independently selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.8 cycloalkyl, phenyl, substituted phenyl, phenyl(C.sub.1 -C.sub.4 alkylene), phenyl(C.sub.1 -C.sub.4 alkylene) substituted in the phenyl ring, ((C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxycarbonyl substituted)C.sub.1 -C.sub.4 alkyl)phenyl, C.sub.1 -C.sub.4 alkyl .alpha.-substituted with C.sub.1 -C.sub.4 alkoxycarbonyl;
• or
• R.sup.10 and R.sup.11 taken together with the nitrogen atom form a pyrrolidine, piperidine, piperazine, 4-substituted piperazine, morpholine or thiomorpholine ring;
• R.sup.12 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, phenyl, substituted phenyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 alkyl .omega.-substituted with C.sub.1 -C.sub.4 alkoxy;
• R.sup.13 is H or C.sub.1 -C.sub.4 alkyl;
• R.sup.14 is C.sub.1 -C.sub.10 alkyl substituted with from one to three substituents selected from the group consisting of hydroxy, C.sub.1 -C.sub.4 alkoxy, halo, aryloxy, C.sub.1 -C.sub.4 alkoxycarbonyl and heteroaryloxy, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, phenyl, substituted phenyl, naphthyl, phenyl(C.sub.1 -C.sub.4 alkylene), phenyl(C.sub.1 -C.sub.4 alkylene) substituted on the phenyl ring, 2-phenylethylen-1yl, diphenylmethyl, benzofused C.sub.4 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 alkylene w-substituted with C.sub.3 -C.sub.6 cycloalkyl, or a heterocycle;
• R.sup.15 is H or C.sub.1 -C.sub.6 alkyl;
• and pharmaceutically acceptable acid addition salts and solvates thereof.