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US 5,708,007 AGranted
2-(piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl) benzofuran-7-ol and carbamate derivatives for treating memory dysfunction
AssigneeHoechst Marion Roussel, Inc.
InventorsGerard J. O'Malley, Udo Hedtmann
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Abstract
These are disclosed novel 2-(piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)benzofuran-7-ol and carbamate derivatives of the formula ##STR1## where the substituents are as defined in the specification, which are useful as acetylcholinesterase inhibitors and as such may be useful for the treatment of Alzheimer's disease and other senile dementias.
Claims13
A compound of the formula ##STR32## wherein R.sub.1 is CONHR.sub.11 or CONR.sub.6 R.sub.7
- R.sub.2 is hydrogen, cyano, CH.sub.2 NR.sub.8 R.sub.9, CONHR.sub.5 or CONR.sub.6 R.sub.7 ;
- R.sub.3 is ##STR33## where R.sub.10 is hydrogen, loweralkyl, arylloweralkyl, CONHR.sub.5, CONR.sub.6 R.sub.7, acyl, acyloxyloweralkyl or acyloxyarylloweralkyl;
- R.sub.4 is hydrogen, halogen, loweralkyl or loweralkoxy;
- R.sub.5 is hydrogen, loweralkyl or arylloweralkyl;
- R.sub.6 is loweralkyl or arylloweralkyl;
- R.sub.7 is loweralkyl or arylloweralkyl;
- R.sub.8 is hydrogen, loweralkyl, arylloweralkyl or acyl;
- R.sub.9 is hydrogen, loweralkyl or arylloweralkyl;
- R.sub.11 is loweralkyl, aryl or arylloweralkyl;
- or a pharmaceutically acceptable acid addition salt thereof, or, where applicable, an optical or geometric isomer or racemic mixture thereof.
7 more elements
Dependencies are inferred from the claim text.