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US 5,708,002 AGranted
Macrocyclic immunomodulators
AssigneeAbbott Laboratories
InventorsJay R. Luly, Megumi Kawai, Yat Sun Or, Paul Wiedeman, Rolf Wagner
Life of this patent
Estimating the term…
Abstract
Immunomodulatory macrocyclic compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is selected from one of the formulae ##STR2## as well as pharmaceutical compositions containing the same.
Claims7
A compound of the formula:
- ##STR18## wherein X is ##STR19## and (a) R=ethyl;
- R'=R2=R3=H;
- n=1;
- R.sup.1' =--OCH.sub.3 ;
- and R.sup.1 =CH.sub.3 C(O)S-- (S Configuration);
- or
- (b) R=ethyl;
- R'=R2=R3=H;
- n=1;
- R.sup.1' =--OCH.sub.3 ;
- and R.sup.1 =C.sub.6 H.sub.5 S--;
- or
- (c) R=ethyl;
- R'=R2=R3=H;
- n=1;
- R.sup.1' =--OCH.sub.3 ;
- and R.sup.1 =benzylthio;
- or
- (d) R=ethyl;
- R'=R2=R3=H;
- n=1;
- R.sup.1' =--OCH.sub.3 ;
- and R.sup.1 =--SH;
- or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
21 more elements
A compound of the formula:
- ##STR20## wherein X is ##STR21## and R=ethyl;
- R'=R2=R3=H;
- n=1;
- R.sup.1' =--OCH.sub.3 ;
- R.sup.1 =N-tetrazole (S-Configuration);
- or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
3 more elements
Dependencies are inferred from the claim text.