US 5,707,998 A · Nitrogen-containing fused-heterocycle compounds

Abstract

The present invention relates to a nitrogen-containing heterocyclic compound exhibiting an inhibitory activity against cGMP-PDE. The compound represented by the formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1 represents a group represented by the formula: --NR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 each represent hydrogen, lower alkyl or the like) or the like; R.sup.2 represents a group represented by the formula: ##STR2## (wherein R.sup.8 represents a carboxyl group which may be protected, or the like) or the like; and R.sup.3 represents a group represented by the formula: ##STR3## (wherein R.sup.6 and R.sup.7 each represent hydrogen, lower alkyl or the like) or the like.

Claims4

Dependent claims

A quinazoline derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof:

##STR49## wherein R.sup.1 is selected from pyrazolyl, imidazolyl, substituted imidazolyl, triazolyl, tetrazolyl, piperidyl, a nitro group or a --NR.sup.5 R.sup.6 group wherein R.sup.5 and R.sup.6 may be the same or different from each other and each represent a hydrogen atom or a lower alkyl group;
R.sup.2 is a hydrogen atom with the proviso when R.sup.1 is an amino group, then R.sup.2 is not a hydrogen atom, a halogen atom or a group represented by the following formula ##STR50## wherein R7 is a hydrogen atom or a lower alkyl group;
R.sup.3 and R.sup.4 each represent a halogen atom or a lower alkoxy group, or together form a methylenedioxy group or ethylenedioxy group.

Dependencies are inferred from the claim text.

Facts

Application

08/525,739Filed 25 Sep 1995

Priority

JP 5-09513131 Mar 1993

Granted

13 Jan 1998

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07D 231/12
Having two or three double bonds between ring members or between ring members and non-ring members: with only hydrogen atoms, hydrocarbon or…
C07D 233/56
Having two double bonds between ring members or between ring members and non-ring members: with only hydrogen atoms or radicals containing only…
C07D 249/08
Not condensed with other rings: 1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
C07D 405/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links

Nitrogen-containing fused-heterocycle compounds

Life of this patent

Nitrogen-containing fused-heterocycle compounds

Life of this patent

Abstract

Claims4