N-acylpyrrolidines and medicaments for the treatment or prevention of disorders linked to CKK and to gastrin

A compound of formula (I):

• ##STR19## in which R represents a phenyl radical optionally substituted by at least one substituent selected from halogen atoms and alkyl, alkoxy, hydroxyl, nitro, amino, monoalkylamino, dialkylamino, alkoxycarbonyl, --CO--NR.sub.7 R.sub.8, --NH--CO--CH.sub.3, trifluoromethyl and trifluoromethoxy radicals,
• R.sub.1 represents a hydrogen atom or an alkyl radical,
• R.sub.2 represents a --(CH.sub.2).sub.n --CO--R.sub.6 or --(CH.sub.2).sub.m --NR.sub.9 R.sub.10 chain,
• R.sub.3 represents a hydrogen atom or an alkyl radical,
• R.sub.4 represents a hydrogen atom or an alkyl radical,
• R.sub.5 represents a phenylamino radical in which the phenyl ring is optionally substituted by at least one substituent selected from halogen atoms and alkyl, alkoxy, alkylthio, trifluoromethyl, carboxyl, alkoxycarbonyl, hydroxyl, nitro, amino, acyl, cyano, sulphamoyl, carbamoyl, hydroxyiminoalkyl, alkoxyiminoalkyl, hydroxyaminocarbonyl, alkoxyaminocarbonyl, 5-tetrazolyl, 5-tetrazolylalkyl, trifluoromethylsulphonamido, alkylsulphinyl, mono- or polyhydroxyalkyl, sulpho, -alk-O--CO-alk, -alk-COOX, -alk-O-alk, -alk'-COOX, --O-alk-COOX, --CH.dbd.CH--COOX, --CO--COOX, -alk-SO.sub.3 --H (in the salt form), --CH.dbd.CH-alk', --C(.dbd.NOH)--COOX, --S-alk-COOX, --SO-alk-COOX, --SO.sub.2 -alk-COOX, --O--CH.sub.2 -alk'-COOX, --CX.dbd.N--O-alk--COOX, -alk-N(OH)--CO-alk, -alk-SO.sub.2 H, --SO.sub.2 --NH--CO--R.sub.13, --SO.sub.2 --NH--SO.sub.2 --R.sub.13, --CO--NH--CO--R.sub.13, --CO--NH--SO.sub.2 --R.sub.13, --B(OH).sub.2, --C(NH.sub.2).dbd.NOH, --SO.sub.2 --NH--R.sub.14, --CO--NH--R.sub.14, ##STR20## and 2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl radicals, R.sub.6 represents a hydroxyl, alkoxy, cycloalkyloxy, cycloalkylalkyloxy, phenyl, or --NR.sub.9 R.sub.10 radical,
• R".sub.6 represents an alkoxy, cycloalkyloxy, cycloalkylalkyloxy, phenyl, or --NR.sub.9 R.sub.10 radical,
• R.sub.7 represents a hydrogen atom or an alkyl radical, phenylalkyl radical or phenyl radical optionally substituted by at least one substitutent selected from halogen atoms and alkyl, alkoxy and alkylthio radicals,
• R.sub.8 represents an alkyl radical, phenylalkyl radical or phenyl radical optionally substituted by at least one substituent selected from halogen atoms and alkyl, alkoxy and alkylthio radicals,
• or else R.sub.7 and R.sub.8 form, with the nitrogen atom to which they are attached, a saturated or unsaturated, mono- or polycyclic heterocycle containing 4 to 9 carbon atoms and at least one heteroatom selected from oxygen and nitrogen, and being optionally substituted by at least one alkyl radical,
• R.sub.9 represents a hydrogen atom or an alkyl radical, cycloalkylalkyl radical, cycloalkyl radical, phenylalkyl radical or phenyl radical optionally substituted by at least one substituent selected, from halogen atoms and alkyl, alkoxy and alkylthio radicals,
• R.sub.10 represents an alkyl radical, cycloalkylalkyl radical, cycloalkyl radical, phenylalkyl radical or phenyl radical optionally substituted by at least one substituent selected from halogen atoms and alkyl, alkoxy and alkylthio radicals,
• or else R.sub.9 and R.sub.10 form, together with the nitrogen atom to which they are attached, a saturated or unsaturated, mono- or polycyclic heterocycle containing 4 to 9 carbon atoms and at least one heteroatom selected from oxygen, nitrogen and sulfur, and optionally being substituted by at least one alkyl radical,
• R.sub.11 represents a hydrogen atom or an alkyl or phenylalkyl radical,
• R.sub.12 represents an alkyl, phenylalkyl, phenylsulphonyl, --(CH.sub.2).sub.p --CO--R.sub.17, cyano, --CXO, --CX.dbd.NOH, --CX.dbd.N--O-alk-COOX, --CHX--OH, --CHX--O--CO-alk, --NH.sub.2 or --NH--CO-alk radical,
• R.sub.13 represents an alkyl radical, a trifluoromethyl radical, a cycloalkyl radical or a phenyl radical optionally substituted by at least one substituent selected from cyano, alkoxy, nitro and amino radicals and halogen atoms,
• R.sub.14 represents a 5-tetrazolyl radical,
• R.sub.15 represents C.dbd.O or S.dbd.O,
• R.sub.16 represents O or C.dbd.O,
• R.sub.17 represents a hydroxyl, alkoxy, cycloalkyloxy, cycloalkylalkyloxy, phenyl, phenylalkoxy, alkyl or --NR.sub.9 R.sub.10 radical,
• n is equal to 0, 1 or 2,
• m is equal to 1 or 2,
• p is equal to 0 or 1,
• X represents a hydrogen atom or an alkyl or phenylalkyl radical,
• alk represents an alkyl or alkylene radical,
• alk' represents a hydroxyalkyl, hydroxyalkylene, alkoxyalkyl or alkoxyalkylene radical,
• it being understood that, except when otherwise mentioned, the alkyl, alkylene and alkoxy radicals and the alkyl, alkylene and alkoxy portions of radicals contain 1 to 4 carbon atoms in a straight or branched chain, the acyl radicals and portions of radicals contain 2 to 4 carbon atoms and the cycloalkyl radicals and portions of radicals contain 3 to 6 carbon atoms,
• or a salt of a compound of formula (I) or an isomer of a compound of formula (I) when said isomer contains at least one asymmetric center.