Watersoluble azole antifungals
AssigneeJanssen Pharmaceutica NV
InventorsJan Heeres, Leo Jacobus Jozef Backx, Luc Alfons Leo Van der Eycken, Frank Christopher Odds, Jean Louis Mesens
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AssigneeJanssen Pharmaceutica NV
InventorsJan Heeres, Leo Jacobus Jozef Backx, Luc Alfons Leo Van der Eycken, Frank Christopher Odds, Jean Louis Mesens
Estimating the term…
A compound of formula (I), ##STR1## an acid or base addition salt thereof or a stereochemically isomeric form thereof, wherein A and B taken together form --N.dbd.CH--, --CH.dbd.N--, --CH.sub.2 --CH.sub.2, CH.dbd.CH--, --C(.dbd.O)--CH.sub.2 --, --CH.sub.2 --C(.dbd.O); D is a radical of formula ##STR2## L is a radical of formula ##STR3## Alk is a C.sub.1-4 alkanediyl radical; R.sup.1 is halo; R.sup.2 is hydrogen or halo; R.sup.3 is hydrogen, C.sub.1-6 alkyl, phenyl or halophenyl; R.sup.4 is hydrogen, C.sub.1-6 alkyl, phenyl or halophenyl; R.sup.5 is hydrogen or C.sub.1-6 alkyl; R.sup.6 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkyloxycarbonyl, or R.sup.5 and R.sup.6 taken together with the nitrogen atom to which they are attached form a heterocyclic ring. Active intermediates, compositions and methods of preparing compounds, compositions are described.
A compound of formula (I), ##STR28## a pharmaceutically acceptable acid or base addition salt thereof or a stereochemically isomeric form thereof, wherein
Dependencies are inferred from the claim text.