Back to results
US 5,707,975 AGranted
Oral formulations on an antifungal
AssigneeJanssen Pharmaceutica NV
InventorsMarc Karel Jozef Fran.cedilla.ois, Willy Maria Albert Carlo Dries
Life of this patent
Estimating the term…
Abstract
The present invention concerns a formulation for oral administration comprising an antifungal, a sufficient amount of a cyclodextrin or a derivative thereof, an aqueous acidic medium as bulk liquid carrier and an alcoholic co-solvent Addition of one or more pharmaceutically acceptable sweeteners and one or more pharmaceutically acceptable flavors thereto yields palatable oral formulations. A process of preparing such formulations and pharmaceutical dosage forms comprising said formulations.
Claims7
A formulation for oral administration comprising:
- (a) itraconazole or saperconazole;
- (b) a sufficient amount of a hydroxypropyl-.beta.-cyclodextrin having an M.S. in the range of 0.3 to 3 and containing less than 5% unsubstituted .beta.-cyclodextrin, to act as a solubilizer for the itraconazole or saperconazole;
- (c) an aqueous acidic medium as bulk liquid carrier;
- (d) from about 1% (v/v) to about 20% (v/v) of an alcoholic co-solvent selected from the group consisting of ethanol, propylene glycol and glycerol;
- (e) one or more pharmaceutically acceptable intense sweeteners plus one or more bulk sweeteners;
- and
- (f) one or more pharmaceutically acceptable flavors.
4 more elements
Dependencies are inferred from the claim text.