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AssigneeAbbott Laboratories
InventorsPradip Mukerji, Amanda Eun-Yeong Seo, Steven Neal Anderson, Linda Ann Harvey
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The attachment of H. influenzae to human cells, such as oropharyngeal cells, may be inhibited by native human .beta.-casein, a recombinant form of human .beta.-casein, and hydrolysates of both. The human .beta.-casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant formula. The enteral nutritional product may be used, for example, in the prevention and treatment of otitis media in infants. The human .beta.-casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.
A method of treating H. influenzae infection in humans comprising administering, via a nasal passageway, a formulation comprising a therapeutically effective amount of at least one material selected from the group consisting of .beta.-casein isolated from human milk, a recombinant form of the .beta.-casein contained in human milk and hydrolysates of both.
A method of treating H. influenzae infection in humans comprising administering an oral formulation comprising a therapeutically effective amount of at least one material selected from the group consisting .beta.-casein isolated from human milk, a recombinant form of the .beta.-casein contained in human milk and hydrolysates of both.
A method of inhibiting the infection of mammalian cells by H. influenzae comprising administering, via a nasal passageway, a formulation comprising a therapeutically effective amount of at least one material selected from the group consisting of .beta.-casein isolated from human milk, a recombinant form of the .beta.-casein contained in human milk and hydrolysates of both.
A method of inhibiting the infection of mammalian cells by H. influenzae comprising administering an oral formulation comprising a therapeutically effective amount of at least one material selected from the group consisting of .beta.-casein isolated from human milk, a recombinant form of the .beta.-casein contained in human milk and hydrolysates of both.
Dependencies are inferred from the claim text.