Peptides for control of intestinal motility

An electrophoretic homogenous Coherin A product prepared by the process comprising

• (a) subjecting Coherin to continuous flow electrophoresis under conditions effective to separate therefrom a fraction having the ability to control intestinal motility and exhibiting the following characteristics:
• (i) .lambda. maximum at 274 nm at pH 1;
• (ii) .lambda. maximum at 240 nm and 290 nm at pH 11;
• (iii) .lambda. minimum at 248 nm at pH 1;
• (iv) .lambda. minimum at 233 and 272 nm at pH 11;
• (v) isoelectric point at pH=6;
• (vi) molecular weight ranging from 300 to 600;
• (vii) soluble in water, slightly soluble in absolute ethanol and insoluble in acetone;
• and
• (viii) containing glycine, said product being substantially free of Coherin, Coherin A.sub.1, Coherin A.sub.2, Coherin B and Coherin C;
• (b) collecting said fraction;
• and
• (c) lyophilizing the collected fraction.